The MB-PAT PAT-MIND advanced-cancer demoralization trial will report positive topline on primary endpoint within 12 weeks, expanding the palliative-care use case.

A clinical trial called PAT-MIND is testing whether psilocybin-assisted therapy (a guided experience using the active ingredient in magic mushrooms) can help cancer patients cope with the crushing emotional despair that often comes near end of life. Researchers expect positive results within 12 weeks, based on the fact that similar studies have consistently shown large improvements in how patients feel. If confirmed, this would strengthen the case for using psilocybin in palliative care — care focused on comfort rather than cure.

Existential distress trials (cancer) historically show large psilocybin effect sizes; PAT-MIND is designed on that precedent. This is the strongest signal category.