No Schedule I psychedelic is rescheduled or descheduled federally in 2026.

In the US, making a drug like psilocybin or MDMA legal at the federal level first requires sign-off from the FDA (the US drug regulator). That sign-off isn't coming this year, and there's no other legal path open. So the federal rules stay the same: these substances remain fully illegal under federal law.

Rescheduling requires FDA approval first, which Holloway confirms won't come this year. The empty docket removes any legislative route. Enforcement posture holds.