Within the next 18 months, the federal government is very unlikely to move psilocybin or MDMA out of Schedule I — the category reserved for drugs the government considers to have no accepted medical use. This matters because Schedule I status makes research harder and keeps these substances illegal at the federal level regardless of state laws.
Rescheduling is politically premature pre-approval. Congress prefers access pilots to CSA changes. Mendez's constituency still holds veto power.