Psilocybin mechanistic/imaging findings replicate robustly while disease-specific claims require correction.

Scientists are finding solid, repeatable evidence about how psilocybin physically changes brain activity and connectivity — those findings are holding up. But specific claims like 'psilocybin cures depression' or 'it treats addiction' are being overstated and will need to be walked back as more rigorous studies come in.

The neuroscience of 2A-mediated connectivity is extraordinary and durable. But clinical translation is being rushed. Mechanism is the foundation that prevents failed replications.