The DEA (the US agency that controls which drugs are legal) can only move a drug out of its most restricted category after the FDA (the US drug regulator) approves it as medicine. Since no psychedelic drug is close to FDA approval, nothing changes in 2026. People caught with psilocybin, LSD, DMT, or mescaline still face full federal criminal penalties.
DEA rescheduling is statutorily gated on prior FDA approval, which is not imminent. With no NDA approval expected in 2026, the scheduling status quo holds.