Even if the president orders it, the DEA (Drug Enforcement Administration) must follow a specific law that requires an 8-step review and approval from the health department before it can reschedule any drug. This process takes at least 18 months and no executive order can skip it. You won't see MDMA or psilocybin moved off Schedule I before spring 2027.
Controlled Substances Act Section 811 requires DEA to conduct an eight-factor analysis and obtain a binding HHS scientific and medical evaluation before rescheduling. These are statutory requirements — no executive order can waive them. DEA's own administrative law counsel enforces this. The fastest documented rescheduling (marijuana CBD) took over 18 months after HHS recommendation. Any Trump 'fast-track' EO on psychedelics is legally constrained to the same pipeline. Falsifiable: rescheduling either takes effect or it doesn't.