Someone has already died at an unregulated retreat using toad venom (a powerful psychedelic extracted from toads). This death gives the DEA (Drug Enforcement Administration) both a public safety reason and political cover to arrest operators running illegal psychedelic retreats, especially in cities where psilocybin has been decriminalized but not legalized.
A high-profile toad venom (5-MeO-DMT) death provides DEA with a concrete public safety predicate and Congressional cover to act. DEA has existing Schedule I statutory authority over psilocybin, DMT, and 5-MeO-DMT. Unregulated retreats operating openly in post-decriminalization cities present an enforcement gap that becomes politically untenable after a fatality. Two actions is a conservative threshold — one is nearly certain, two is achievable given resource allocation post-incident.