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Psilocybin cocaine RCT extinction-without-relapse-prevention finding will generate 3+ follow-up mechanistic studies within 18 months investigating default mode network suppression during extinction learning.

Predicted 2026-05-18 · Resolves 2027-11-18 · research · Global
79%
ORACLE CONFIDENCE
⏳ Pending
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Scientists just found that psilocybin (the active compound in magic mushrooms) helps people learn to stop craving cocaine without needing the usual relapse prevention therapy. Neuroscientists will now run 3+ new studies to figure out exactly which brain circuits make this work, because it's a genuinely novel mechanism that could unlock new addiction treatments.

The extinction-without-relapse split is a clean neuroscience puzzle — it separates learning consolidation from cue-reactivity circuitry. That is exactly the kind of mechanistic question that generates NIH R01 applications. The data is compelling enough to fund.

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